About BioPQQ

Brief Introduction of PQQ

PQQ
  • Coenzyme concerning redox cycling identified in 1979
  • Water-soluble compound (reddish brown powder)

Distribution
  • In daily foods and beverages
  • In human tissues, organs and human milk
Safety
  • NOAEL > 100mg/kg/day (rat, 90-day, oral)
  • Core batteries of genotoxicity study: Negative
  • Human clinical study (20 and 60mg/day): No toxicity
Functions
  • Neuroprotective activity
  • Anti-oxidative activity
  • Mitochondrial biogenesis
Present situation
  • NDI(New Dietary ingredients) review accepted by FDA
    (“Life Sciences Research Office” reached positive conclusion)
  • Food-grade PQQ is supplied in US market only from MGC

Key milestone

1979 Salisbury SA et al. (Nature)
& Duine JA et al.
PQQ was discovered from microorganisms as a cofactor for alcohol dehydrogenases.
1987 MGC Started supplying PQQ as a reagent for research purpose
1989 Killgore J et al. (Science) PQQ-deficiency symptoms in mice were discovered.
2003 Kasahara T et al. (Nature) PQQ should be classified as a new B vitamin.
2008 MGC NDI review accepted by FDA
Commercialized PQQ